First study on efficacy and tolerability of a new alkylphosphocoline molecule (oleylphosphocoline-OIPC) in the treatment of canine leishmaniosis due to Leishmania infantum

Reseña Parasitology Research 2014; 113(1): 157-164. Enlace
Autores

Hernández L, Gálvez R, Montoya A, Checa R, Bello A, Bosschaerts T, Jansen H, Rupérez C, Fortin A, Miró G

Reseña

En los últimos años se están  desarrollando nuevas moléculas candidatas a fármacos con  actividad leishmanicida como la oleilfosfocolina (OIPC), análogo de la miltefosina. Una de las ventajas que tiene este tratamiento es que su administración es por vía oral. Se ha testado su eficacia en un ensayo clínico preliminar, observando una disminución en el número y gravedad de los signos clínicos en perros infectados de forma natural por L. infantum.

Resumen

The alkylphosphocholine oleylphosphocholine (OlPC) represents a potential new therapy for the treatment of canine leishmaniosis caused by Leishmania infantum. The aim of the present study was to evaluate the efficacy and safety of OlPC in a small cohort of dogs naturally infected with L. infantum and defined as clinically sick (LeishVet stages II and III). A total of eight dogs were included in the study and were treated orally with 4 mg/kg OlPC for 14 days. Dogs were assessed at the clinical and parasitological level at four time points during a total follow-up period of 90 days (before treatment and at 15, 30, and 90 days post-treatment onset). Ln-PCR, real-time quantitative PCR, antibody testing (IFAT), and culture of bone marrow aspirates were evaluated at the four time points. OlPC treatment induced a rapid and satisfactory clinical recovery in terms of clinical score reduction and weight gain, and treatment efficacy was found to be associated with a decrease in bone marrow parasitic load. Serological titers measured by IFAT were stable in any of the treated dogs at any time point after treatment. OlPC was well tolerated and no severe adverse events were noted in any of the treated dogs; even some dogs showed slight intestinal disorders. This proof-of-principle study is the first to show that short oral treatment with OlPC improves clinical signs of canine L. infantum leishmaniosis, highlighting the need to perform additional studies to optimize the dosing regimen and to assess long-term treatment efficacy of this drug.

Referencia del grupo

Epicontrol y Parasitosis carnívoros

Facultad de Veterinaria, Universidad Complutense

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