Proteomic profile of Bithynia siamensis goniomphalos snails upon infection with the carcinogenic liver fluke Opisthorchis viverrini

Reseña Journal of Proteomics January 2015, pp.281-291, doi:10.1016/j.jprot.2014.09.018       Enlace
Autores Prasopdee, S.; Tesana, S.; Cantacessi, C.; Laha, T.; Mulvenna, J.; Grams, R.; Loukas, A.; Sotillo, J.
Contribución A pesar de la importancia de diversas especies de caracoles en la transmisión de muchos helmintos, se han realizado pocos estudios a nivel molecular para determinar los cambios que provoca el parásito en su hospedador intermediario. En este estudio hemos analizado estos cambios a nivel proteómico en el caracol Bythinia siamensis goniomphalos (hospedador intermediario de Opisthorchis viverrini) como punto de partida para la determinación de las proteínas implicadas en la susceptibilidad/resistencia de B. siamensis goniomphalos frente a O. viverrini así como en otros sistemas parásito-hospedador.
Resumen The snail Bithynia siamensis goniomphalos acts as the first intermediate host for the human liver flukeOpisthorchis viverrini, the major cause of cholangiocarcinoma (CCA) in Northeast Thailand. The undisputed link between CCA and O. viverrini infection has precipitated efforts to understand the molecular basis of host–parasite interactions with a view to ultimately developing new control strategies to combat this carcinogenic infection. To date most effort has focused on the interactions between the parasite and its human host, and little is known about the molecular relationships between the liver fluke and its snail intermediate host. In the present study we analyse the protein expression changes in different tissues of B. siamensis goniomphalos induced by infection with larval O. viverrini using iTRAQ labelling technology. We show that O. viverrini infection downregulates the expression of oxidoreductases and catalytic enzymes, while stress-related and motor proteins are upregulated. The present work could serve as a basis for future studies on the proteins implicated in the susceptibility/resistance of B. siamensis goniomphalos to O. viverrini, as well as studies on other pulmonate snail intermediate hosts of various parasitic flukes that infect humans.
Grupo de investigación Centre for Biodiscovery and Molecular Development of Therapeutics, James Cook University, Cairns, Queensland, Australia © James Braun
Luismi

http://www.nhmrc.gov.au/research-highlights/profile/professor-alex-loukas

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