First molecular detection of Leishmania tarentolae-like DNA in Sergentomyia minuta in Spain

Reseña Parasitol Res. 2015 Dec 22. . Enlace
Autores Bravo-Barriga D, Parreira R, Maia C, Blanco-Ciudad J, Afonso MO, Frontera E, Campino L, Pérez-Martín JE, Serrano Aguilera FJ, Reina D.
Contribución This study presents the first detection of Leihmania tarentolae-like DNA in a sand fly from the Sergentomyia minuta in Spain. Additionally, this observation raises environmental concerns, not only because unknown species of reptiles or other animals may be involved in the biological cycle of this Leishmania species but also because its prevalence in putative vectors is unknown. Its pathogenic potential towards humans and other animals should also be investigated.

For this reason, studies that might bring additional insights into the epidemiology of Sauroleishmania and explore the possible role that Sergentomyia may play in the circulation of these parasites in mammals are of paramount importance, especially in countries where leishmaniosis is endemic.

Resumen Phlebotomine sand flies (Diptera, Psychodidae) are vectors of multiple Leishmania species, among which Leishmania infantum stands out as a being frequently pathogenic to humans and dogs in Mediterranean countries. In this study, Sergentomyia minuta sand flies were collected using CDC miniature light traps in different 431 biotopes from Southwest Spain. A total of 114 females were tested for the presence of Leishmania DNA by targeting ITS-1 and cyt-B sequences by PCR. Leishmania DNA was detected in one S. minuta. Characterization of the obtained DNA sequences by phylogenetic analyses revealed close relatedness with Leishmania tarentolae Wenyon, 1921 as well as with both human and canine pathogenic strains of Asian origin (China), previously described as Leishmania sp. To our knowledge, this is the first report of phlebotomine sand flies naturally infected with L. tarentolae-like in Spain. The possible infection of sand flies with novel Leishmania species should be taken into consideration in epidemiological studies of vector species in areas where leishmaniosis is endemic.
Grupo de investigación

Departamento de Sanidad animal, Unidad de Parasitología, Facultad de Veterinaria, Cáceres.

Grupo Parasitoex

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Colaboración especial de:

Unidade de Parasitologia Médica e Unidade de Parasitologia e Microbiologia Médicas

Instituto de Higiene e Medicina Tropical (IHMT)

Universidade Nova de Lisboa (UNL), Portugal.

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Virus Zika: una emergencia internacional

Nos encantaría contar con tu presencia, el próximo jueves 18 de febrero, en la Jornada sobre el Virus Zika, organizada por la Red de Investigación Colaborativa en Enfermedades Tropicales (RICET) y la Escuela Nacional de Sanidad, en la que hablaremos, entre otras cosas, sobre las claves para la preparación y respuesta en España.

Jornada:

Virus Zika: una emergencia internacional

Jueves 18 de febrero de 2016

  Escuela Nacional de Sanidad Aula “Pittaluga”

C/ Sinesio Delgado 10, Pabellón 8 28029 Madrid

 

Presenta: Agustín Benito LlanesDirector Centro Nacional de Medicina Tropical

10:00 – 10:30. Epidemiología de la enfermedad por virus Zika.  Elena Rodríguez Valín Centro Nacional de Epidemiología

 10:30 – 11:00. Características virológicas del virus Zika. Ana Vázquez. Laboratorio de Arbovirus y Enfermedades Víricas Importadas. Centro Nacional de Microbiología.

 11:00 – 11:30. Aspectos clínicos de la fiebre de Zika: Características clínicas, diferencias con dengue y chikungunya.Fernando de la Calle. Hospital La Paz-Carlos III

 11:30 – 12:00 El diagnóstico en España. Mª Paz Sánchez-Seco.Laboratorio de Arbovirus y Enfermedades Víricas Importadas. Centro Nacional de Microbiología.

 12:00 – 12:45 Descanso

 12:45 – 13:15 Vectores potenciales del virus Zika en España: pasado, presente y futuro. Ricardo MolinaLaboratorio de Entomología Médica, Centro Nacional de Microbiología

 13:15 – 13:45 Claves para la preparación y respuesta en España. Carmen Amela Heras. Centro de Coordinación de Alertas y Emergencias Sanitarias. MSSSI

13:45 – 14:30 Discusión

Programas Internacionales de Investigación en Salud para el Desarrollo

Desde el Área Programas Internacionales de Investigación en Salud para el Desarrollo nos envían esta newsletter.

Update 84:  Jan 1 – Jan 31, 2016

PDP Funders Group

Items in blue or purple should be hyperlinked to the full text version; if I have made mistakes many apologies.  If you have any issues that you would like to include in the Update please send them to Alex Fullem (alexfullem@gmail.com).

 

Funder Announcements (since Jan 1 2016)

BMBF                                                                                               
 Jan 2016: Global health in the focus of research- Funding concept: Neglected and poverty-related diseases
DFID
 Jan 25 2016: The Ross Fund – Combatting the world’s most serious diseases

 

PDP Press Releases (since Jan 1 2016)

IAVI                                                                                                
•    5 Jan 2016: Modeling shows a vaccine is essential to conclusively ending HIV/AIDS

·              15 Jan 2016: Study provides additional insights for AIDS vaccine design

FIND
•    6 Jan 2016: Report: Malaria RDT product testing – Round 6 results (WHO, 2015)

•    27 Jan 2016: Experts conclude interim results look good for second-generation HAT RDT

•    28 Jan 2016: Summary from meeting on diagnostic needs for Plasmodium vivax malaria

•    28 Jan 2016: FIND signs partnership agreement with McGill on TB diagnostics

IVCC
25 Jan 2016: Bill Gates and George Osborne visit IVCC
DNDi
13 Jan 2016: Clinical research Malaysia and the Drugs for Neglected Diseases initiative sign agreement to launch clinical studies for a public health approach to Hepatitis C in Malaysia
Sabin
 •   5 Jan 2016: Axel Hoos, Peter Thoren appointed Chairman, Vice Chairman of Sabin Board of Trustees

•    13 Jan 2016: Kenneth Kelley and Jordan Orange join Sabin Vaccine Institute Board of Trustees

TB Alliance
4 Jan 2016: Phase 1 TBA-354 placed on clinical hold

 

Recently released PDP related reports/ briefing papers/ articles/blogs

•   2 Jan: Access to advanced medicines and affordability: a look forward to 2016. Hyderus

•   5 Jan: “We need more money for R&D on diseases of poverty!“. Rural21

•   12 Jan: The troubled quest to find a better mosquito repellent. The Atlantic

•   13 Jan: Atomo secures US$6M from the Global Health Investment Fund. Ide

•   13 Jan: Obama highlights global health and innovation in State of the Union. GHTC

•   13 Jan: Preparing for pandemics could cost less than $1 each year, a review says. Reuters

•   15 Jan: Harnessing health innovation to achieve the global goals. GHTC

•   19 Jan: Gates Foundation accused of “dangerously skewing” aid priorities by promoting “corporate globalisation”. The Independent

•   20 Jan: Vaccines alliance signs $5 million advance for Merck’s ebola shot. Reuters

•   20 Jan: To fight “superbugs”, drug makers call for incentives to develop antibiotics. New York Times

•   21 Jan: U.S. launches “full-court press” for a Zika vaccine. Time

•   21 Jan: Health threats spur vaccine hunt. The Wall Street Journal

•   22 Jan: WHO’s doing what?. GHTC

•   25 Jan: Global pharma groups reveal tie-up with universities. Financial Times

•   27 Jan: Obama urges development of tests, treatments for Zika virus. Voice of America

•   28 Jan: Zika virus spreading explosively, says WHO. The Guardian

 

 New PDP Publications (Since Jan 1 2016)

•  Falling Short: Ensuring access to simple, safe and effective first-line medicines for tuberculosis. TB Alliance and partners. Jan 2016

 MMV at a glance. MMV. Jan 2016

 

Other Reports /Publications (Since Jan 1 2016)

•    Video: Why is health R&D critical to achieving the SDGs?. GHTC. Jan 8 2016.

•    Follow-up of the report of the Consultative Expert Working Group on Research and Development: Financing and Coordination. WHO. Dec 18 2015.

•    Perspectives on strengthening linkages between research, policy and practice. Share-Net. Jan 2016.

•    Advocating female condoms. A reflection on stakeholders commitments & trends in support for female condoms. Share-Net. Jan 2016.

 

Peer-Reviewed Articles (Since Jan 1 2016)

•  Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technology, Li Y, et al., Nature, DOI: 10.1038/srep18848. Jan 8 2015.

•  Market assessment of tuberculosis diagnostics in India in 2013, TB Diagnostics Market Analysis Consortium, Int J Tuber Lung DIS, DOI: doi.org/10.5588/ijtld.15.0571. Jan 12 2016.

•  Market assessment of tuberculosis diagnostics in China in 2012, TB Diagnostics Market Analysis Consortium, Int J Tuber Lung DIS, DOI: doi.org/10.5588/ijtld.15.0156. Jan 12 2016.

 

PDP Disease Area Related News/ Articles (since Jan 1 2016)

HIV/AIDS •   6 Jan: Develop, demonstrate, deliver: Model shows AIDS vaccine is essential to conclusively end epidemic. AVAC
TB •   4 Jan: Tuberculosis drug designed for children nears market. The Guardian

•   12 Jan: USAID announces new partnership to combat MDR-TB. Science Speaks

•   14 Jan: Welcoming the National Action Plan for Combating Multidrug-resistant tuberculosis: Important first steps, critical next steps. GHTC

•   25 Jan: TB: With a plan on the table, an outbreak at home, U.S. Senators, UN Envoy urge White House to fund tuberculosis programs. Science Speaks`

•   27 Jan: Survey shows Xpert TB diagnosis costly, out of reach in countries where private care predominates. Science Speaks

Malaria •   2 Jan: Breakthrough technology has power to stop malaria. Voice of America

•   6 Jan: Malaria drug could be useful against ebola. STAT

•   6 Jan: WHO releases results from reviews of rapid malaria tests. Vaccine News Daily

•   12 Jan: ABIVAX announces positive top-line clinical Phase 11a data for novel HIV drug-candidate ABX464. Medical News Today

•   17 Jan: Obama’s goal to wipe out malaria may be a dream too far. New York Times

•   17 Jan: Obama’s upbeat message about ending malaria omits discouraging signs. NPR

•   19 Jan: “Rallying the world” to defeat malaria. USAID

•   21 Jan: Stopping the spread of malaria. Al Jazeera America

•   25 Jan: British government and Bill Gates announce £3bn to fight malaria. Guardian

•   25 Jan: Britain and Bill Gates to announce £3 billion to eradicate malaria. Yahoo News

NTDs •   7 Jan: Looking for new funding models to address an ancient problem. Devex

•   8 Jan: Device promises faster schistosomiasis diagnosis. SciDevNet

•   11 Jan: River blindness vaccine “major step closer” for Africans menaced by disease. BT

•   21 Jan: Scientists are finally putting sleeping sickness to bed. Van Winkle’s

 

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